Ethan Hunt and his IMF team embark on their most dangerous mission yet: To track down a terrifying new weapon that threatens all of humanity before it falls into the wrong hands. With control of the future and the world's fate at stake and dark forces from Ethan's past closing in, a deadly race around the globe begins. Confronted by a mysterious, all-powerful enemy, Ethan must consider that nothing can matter more than his mission—not even the lives of those he cares about most.

By 2017, the global economy has collapsed and U.S. society has become a totalitarian police state, censoring all cultural activity. The government pacifies the populace by broadcasting a number of game shows in which convicted criminals fight for their lives, including the gladiator-style The Running Man, hosted by the ruthless Damon Killian, where “runners” attempt to evade “stalkers” and certain death for a chance to be pardoned and set free.